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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, <t>FDX1</t> expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.
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Image Search Results


Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, FDX1 expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.

Journal: Cell reports

Article Title: Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.

doi: 10.1016/j.celrep.2024.114424

Figure Lengend Snippet: Figure 6. Validation of the metabolic features in an in-house SDPH cohort (A) Metabolic signature profiling of transcriptomic and metabolites profiling of metabolomic among the MSPG and MSC subgroups in in-house SDPH-GC cohort (n = 33). (B) Comparison of the MSPG score, FDX1 expression, cuproptosis, and mismatch repair score among distinct MSC subtypes. (C) Correlations between MSPG score and the known biological signatures curated from Zeng et al. studies with Spearman analysis. The negative and positive correlations are marked with blue and red color. (D) GSVA analysis of representative KEGG pathway among three MSC subtypes in SDPH dataset. Heatmap shows normalized mean enrichment scores of the enriched molecular pathway in three MSC subtypes.

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies FDX1 Proteintech Cat# 12592-1-AP; RRID:AB_11182486 LIAS Proteintech Cat# 11577-1-AP; RRID:AB_2135972 DLD Proteintech Cat# 16431-1-AP; RRID:AB_2091888 DLST abcam Cat# ab177934 DLAT Proteintech Cat# 13426-1-AP; RRID:AB_2091774 PDHA1 Proteintech Cat# 18068-1-AP; RRID:AB_2162931 PDHB Proteintech Cat# 14744-1-AP; RRID:AB_2162941 GLS Proteintech Cat# 29519-1-AP; RRID:AB_2918320 IDH1 abways Cat# CY8115 OGDH SAB Cat# 29113 GLS abways Cat# CY5719 TYMS abways Cat# CY7089 ENO2 abways Cat# CY5656 LDHA abways Cat# CY8276 b-actin Proteintech Cat# 20536-1-AP; RRID:AB_10700003 Biological samples

Techniques: Biomarker Discovery, Comparison, Expressing